Journal Facts

Journal
BoneKEy Reports
ISSN
2047-6396
Volume
4
Year
2015

Article Facts

Title
Mechanisms of osteolytic and osteoblastic skeletal lesions
DOI
10.1038/bonekey.2015.122
Authors

G David Roodman
Rebecca Silbermann

Online Date
10/28/2015

Article Links

BoneKEy Reports | Reviews

Mechanisms of osteolytic and osteoblastic skeletal lesions

G David Roodman
Rebecca Silbermann


DOI:10.1038/bonekey.2015.122

Abstract

The bone is a frequent site for tumor metastasis, and cancer in the bone results in marked disturbances of bone remodeling that can be lytic, blastic or a combination of the two. Patients with advanced malignancies that have metastasized to the bone frequently suffer from debilitating skeletal-related events, including pathologic fractures, spinal cord compression syndromes, disorders of calcium and phosphate homeostasis and severe cancer-related pain. This review will discuss recent studies on the mechanisms responsible for osteolytic and osteoblastic metastasis and how their identification has resulted in the development of new agents for patients with metastatic bone disease.

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