CASE REPORT |
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Year : 2014 | Volume
: 20
| Issue : 1 | Page : 69-71 |
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Chronic myeloid leukemia in case of Klinefelter syndrome
Vasundhara Chennuri, Rajesh Kashyap, Parag Tamhankar, Subha Phadke
Departments of Hematology, and 1Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Correspondence Address:
Rajesh Kashyap , Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Barely Road, Lucknow 226 014, Uttar Pradesh India
Source of Support: None, Conflict of Interest: None
DOI: 10.4103/0971-6866.132760
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Klinefelter syndrome (KS) is a sex chromosome disorder and has been reported to be associated with increased risk for malignancies. We report a 22-year-old male patient who was diagnosed to have chronic myeloid leukemia in chronic phase. Bone marrow cytogenetic examination revealed karyotype 47, XXY, t (9; 22)(q34, q11) suggestive of KS with presence of Philadelphia chromosome. The patient was treated with oral imatinib mesylate (400 mg/day). Complete hematological response was achieved after 2 months of therapy. The bcr-abl/abl transcript percentage measured from peripheral blood at baseline, 1 and 2 years after imatinib were 97%, 1.99%, 0.007%, respectively. He remains in complete hematological and major molecular remission after 2 years of continued imatinib therapy. |
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