Indian Journal of Human Genetics
Home Current Issue Archives Guidelines Subscriptions e-Alerts Login 
Users online: 18
Print this page  Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2013  |  Volume : 19  |  Issue : 2  |  Page : 188-195

CD14 C-159T polymorphism and its association with chronic lung diseases: A pilot study on isocyanate exposed population of Central India


1 Department of Research, Bhopal Memorial Hospital and Research Center, Madhya Pradesh, India
2 Department of Pulmonary Medicine, Bhopal Memorial Hospital and Research Center, Madhya Pradesh, India
3 Department of Surgical Gastroenterology, Bhopal Memorial Hospital and Research Center, Madhya Pradesh, India

Correspondence Address:
Protiti Bose
H35, Apsara Complex, Indrapuri, Sector-A, Bhopal, Madhya Pradesh
India
Login to access the Email id

Source of Support: Bhopal Memorial Hospital and Research Centre, Conflict of Interest: None


DOI: 10.4103/0971-6866.116124

Get Permissions

Context: CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to influence the cytokine profile and subsequent immunoglobulin E production in response to antigen/allergen contact in allergic phenotypes. Aims: The present study was to investigate genetic polymorphism in CD14 gene - 159C/T, which may be one of the risk factor for increased prevalence of Chronic Lung Diseases in the Central India. Settings and Design: Survivors of Methyl isocyanates toxicity in Bhopal still suffering from various respiratory ailments were examined. Materials and Methods: Polymerase chain reaction-restriction fragment length polymorphism was performed to determine the polymorphism of C-159T. Statistical analysis used: All analysis was done using SPSS software, version 11.5 (SPSS, Chicago, IL, USA). Results: The genotype and allelic frequencies were in Hardy-Weinberg's equilibrium. Prevalence of CC, CT, and TT were 5.5%, 22.2% and 9.25% respectively in asthmatics; 16.6%, 20.3% and 5.5% respectively in chronic obstructive pulmonary disease (COPD) patients and 5.5%, 14.8% and 1.85 respectively among interstitial lung disorder (ILD) patients; whereas the control cohort with no methyl isocyanate exposure displayed (CC, CT, and TT) cytosine,thymine as 2%, 1.6% and 2% respectively. Increased risk of Asthma among those carrying TT genotype and T allele (odds ratio [OR] =2.61 and 2.02 respectively). Conclusion: COPD risk significantly found among those with CC genotype and C allele (OR = 2.81 and 1.50 respectively), whereas ILD risk found significantly among CT genotype and C allele (OR = 1.75 and 1.40 respectively). Therefore, single nucleotide polymorphism (SNP) C-159T polymorphism in CD14 gene might be a risk factor for development of CLD in this population.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1270    
    Printed24    
    Emailed0    
    PDF Downloaded48    
    Comments [Add]    
    Cited by others 1    

Recommend this journal