| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 19
| Issue : 1 | Page : 65-70 |
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Distribution of CC-chemokine receptor-5-∆32 allele among the tribal and caste population of Vidarbha region of Maharashtra state
Arvind B Chavhan1, Santosh S Pawar2, Rajusing G Jadhao3, Kishor G Patil4
1 Department of Zoology, Shri Shivaji Science College, Amravati; Institute of Science, Nagpur, India
2 Department of Zoology, Govt. Vidarbha Institute of Science and Humanities, Amravati, Maharashtra, India
3 Department of Zoology, Shri Shivaji Science College, Amravati, India
4 Department of Zoology, Institute of Science, Nagpur, India
Correspondence Address:
Arvind B Chavhan
Department of Zoology, Shri Shivaji Science College, Morshi Road, Amravati, Maharashtra
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/0971-6866.112894
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Background: Genetic relationships among the ethnic groups are not uniform across the geographical region. Considering this assumption, we analyzed the frequency of the CC-chemokine receptor-5 (CCR5)-∆32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in Bhil tribal and Brahmin caste sample sets from the population.
Materials and Methods: 108 blood samples were collected from 6 tribe's populations and a caste population from the district of Vidarbha region.
Results and Discussion: The presence of low frequencies of CCR5-Δ32 in an individual of Bhil tribe (0.034, χ2 value 0.017) in the present study implies that these communities may have a better resistance toward human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) than the other studied tribe sample, as non-show such mutation.
Conclusion: The marginal presence of the allele seen in the studied tribal population could be due to gene flow from the people of European descent. However, lack of the homozygous CCR5-Δ32 mutation and the low prevalence of heterozygous CCR5-Δ32 mutations suggest that the Indians are highly susceptible to HIV/AIDS, and this correlates with the highest number of HIV/AIDS infected individuals in India. |
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