Indian Journal of Human Genetics
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ORIGINAL ARTICLE
Year : 2012  |  Volume : 18  |  Issue : 2  |  Page : 198-203

Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review


1 Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2 Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
3 Department of Urology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Obstetrics and Gynecology, Mirza Kouchak Khan Women Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Mohammad T Akbari
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares` University, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.100764

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Background: Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population. Materials and Methods: The records of a total of 222 participants were evaluated retrospectively. Results: As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities. Conclusion: Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.


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