Indian Journal of Human Genetics
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Year : 2012  |  Volume : 18  |  Issue : 1  |  Page : 66-70

Karyotypic findings in chronic myeloid leukemia cases undergoing treatment

1 Centre for Genetic Disorders, Guru Nanak Dev University, Amritsar, India
2 Department of Pathology, Government Medical College, Amritsar, India
3 Department of Pathology, Central University of Punjab, Bathinda, Punjab, India

Correspondence Address:
Anupam Kaur
Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab - 143 005
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-6866.96654

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Background: Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells. Materials and Methods: In the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana. Results: Chromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission. Conclusion: This is a novel phenomenon whose prognostic implications require thorough and systematic evaluation.

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