| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 18
| Issue : 1 | Page : 66-70 |
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Karyotypic findings in chronic myeloid leukemia cases undergoing treatment
Anupam Kaur1, Simran Preet Kaur1, Amarjit Singh2, Jai Rup Singh3
1 Centre for Genetic Disorders, Guru Nanak Dev University, Amritsar, India
2 Department of Pathology, Government Medical College, Amritsar, India
3 Department of Pathology, Central University of Punjab, Bathinda, Punjab, India
Correspondence Address:
Anupam Kaur
Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab - 143 005
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/0971-6866.96654
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Background: Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells.
Materials and Methods: In the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana.
Results: Chromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission.
Conclusion: This is a novel phenomenon whose prognostic implications require thorough and systematic evaluation. |
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