| BRIEF REPORT |
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| Year : 2012 | Volume
: 18
| Issue : 1 | Page : 109-111 |
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Recombination in human leukocyte antigen region in two Asian Indian families
Mahendra N Mishra1, Ajay Sharma2
1 Department of Pathology, Dr. Lal Path Labs Pvt Ltd, Rohini, New Delhi, India
2 Department of Clinical Haematology and Internal Medicine, Army Hospital Research and Referral, Delhi Cantt., India
Correspondence Address:
Mahendra N Mishra
Pathology, Dr. Lal Path Labs Pvt Ltd, Block E, Sector 18, Rohini, New Delhi - 110 085
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/0971-6866.96674
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Background: Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles.
Settings and Design: A prospective study at a tertiary care centre.
Aim :0 To report two rare cases of crossing over in HLA region.
Materials and Methods: Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples.
Results: In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10.
Conclusions: Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT. |
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