Indian Journal of Human Genetics
Home Current Issue Archives Guidelines Subscriptions e-Alerts Login 
Users online: 11
Print this page  Email this page Small font sizeDefault font sizeIncrease font size
BRIEF REPORT
Year : 2012  |  Volume : 18  |  Issue : 1  |  Page : 109-111

Recombination in human leukocyte antigen region in two Asian Indian families


1 Department of Pathology, Dr. Lal Path Labs Pvt Ltd, Rohini, New Delhi, India
2 Department of Clinical Haematology and Internal Medicine, Army Hospital Research and Referral, Delhi Cantt., India

Correspondence Address:
Mahendra N Mishra
Pathology, Dr. Lal Path Labs Pvt Ltd, Block E, Sector 18, Rohini, New Delhi - 110 085
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.96674

Get Permissions

Background: Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles. Settings and Design: A prospective study at a tertiary care centre. Aim :0 To report two rare cases of crossing over in HLA region. Materials and Methods: Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples. Results: In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10. Conclusions: Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1331    
    Printed84    
    Emailed0    
    PDF Downloaded36    
    Comments [Add]    
    Cited by others 1    

Recommend this journal