Coregulators in Nuclear Estrogen Receptor Action

Table 1.

Coactivators in ER Physiology and Pharmacology

CoFactor Full Name Other Names Function Interaction with ER
AF-2 Coactivators SRC-1 (p160) Steroid receptor coactivator-1 NCoA-1 HAT (Histone acetlytranserase) Binds ERs AF-2 through LXXLL motifs
SRC-2 (p160) Steroid receptor coactivator-2 GRIP1, TIF-2, NCoA-2 HAT Binds ERs AF-2 through LXXLL motifs
SRC-3 (p 160) Steroid receptor coactivator-3 AIB1, ACTR, p/CIP, RAC3, TRAM-1, NCoA-3 HAT Binds ERs AF-2 through LXXLL motifs
CBP/p300 CREB-binding protein HAT Binds ERs AF-2 through LXXLL motifs
TRAP220, TRAP/DRIP Thyroid hormone receptor activating protein of 220 kDa mediator; PBP Binds ERs AF-2 through LXXLL motifs
ASC-1 Activating signal cointegrator-1 Bind HATs and NRs Binds ERs AF-2 through
ASC-2 Activating signal cointegrator-2 RAP250, TRBP, AIB3 LXXLL motifs
AF-1 Coactivators SRA Steroid receptor activator Splicing Binds ERα AF-1
p68 p68 RNA helicase RNA helicase Binds ERα AF-1
Secondary Coactivators CARM1 Protein methyltransferase 1 Arginine histone methyltransferase Binds ERs AF-2 indirectly through association with p160s
PRMT1 Protein methyltransferase 1 Arginine histone methyltransferase Binds ERs AF-2 indirectly through association with p160s
CoCoA Coiled-coil coactivator Binds ERs AF-2 indirectly through association with p160s
Dual- Functional Coactivators E6-AP E6-associated protein Ubiquitin ligase Binds ERs AF-2
RPF-1 Receptor potentiating factor-1 Ubiquitin ligase Binds ERs AF-2
PGC-1α PGC-1β PPARγ coactivator-1 Tethering surface for other cofactors; splicing Binds the hinge region of the ERs
CAPER-alpha CAPER-beta CoAA Coactivator of (AP-1) and estrogen receptors Coactivator activator Potentiate ER activity; splicing Associate with ER indirectly through binding ASC-2

This Article

  1. MI December 2005 vol. 5 no. 6 343-357