Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators

Table 1.

Pharmacophores of SARMs

Chemotype General Chemical Structure I D of Lead Molecule Company Stage of Development*
* Information about stage of development was obtained through company websites. BMS, Bristol-Myers Squibb.
Aryl Propionamide Analogs Graphic Ostarine
 Andarine GTx Inc Ortho Biotech Phase I
 Phase I
Bicyclic Hydantoin Analogs BMS 564929 BMS Phase I
Quinoline Analogs LGD2226 Ligand Pharmaceuticals Phase I
Tetrahydro-quinoline Analogs S-40503 kaken (Japan) Preclinical Discovery

This Article

  1. MI June 2005 vol. 5 no. 3 173-188