Accessory Proteins in the Biogenesis of G Protein-Coupled Receptors

  Figure 2.
Figure 2.

GPCR association with transmembrane accessory proteins in the ER. A summary of the GPCR–protein interactions that are discussed in the text. 1) The GABABR1 receptor associates with homologous GABABR2 in forming the heterodimer (shown exiting the ER) required for vesicular transport to the cell surface. 2) An odorant GPCR has been shown to associate with ODR-4, an essential type II membrane-anchored protein. 3) Receptors CRLR and Drosophila rhodopsin require association with type I membrane proteins, such as RAMPs and NinaA, respectively. 4) The dopamine D1 receptor binds to DRiP78 (possessing two internal transmembrane domains) in coordinating ER export.

This Article

  1. MI December 2001 vol. 1 no. 5 282-287