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  Vol. 3 No. 2, February 1994 TABLE OF CONTENTS
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Rationale for the Use of Oral Fluoroquinolones as Empiric Treatment of Nursing Home Infections

Jack D. McCue, MD

Arch Fam Med. 1994;3(2):157-164.


References
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1. Jacobson C, Strausbaugh LJ. Incidence and impact of infection in a nursing home care unit. Am J Infect Control. 1990;18:151-159. PUBMED
2. Tresch DD, Simpson WM, Burton JR. Relationship of long-term and acute-care facilities: the problem of patient transfer and continuity of care. J Am Geriatr Soc. 1985;33:819-826. PUBMED
3. Irvine PW, Van Buren N, Crossley K. Causes for hospitalization of nursing home patients: the role of infection. J Am Geriatr Soc. 1984;32:103-107. PUBMED
4. Cunha BA, ed. Infectious Disease in the Elderly. Littleton, Mass: PSG Publishing Co Inc; 1988.
5. Niederman MS. Respiratory Infections in the Elderly. New York, NY: Raven Press; 1991.
6. Hazzard WR, Andres R, Bierman EL, Blass JP, eds. Principles of Geriatric Medicine and Gerontology. New York, NY: McGraw-Hill International Book Co; 1990.
7. Gleckman RA, Gant NM, eds. Infections in the Elderly. Boston, Mass: Little Brown & Co Inc; 1983.
8. Valenti WM, Trudell RG, Bentley DW. Factors predisposing to oropharyngeal colonization with gram-negative bacilli in the aged. N Engl J Med. 1978;298:1108-1111. PUBMED
9. Irwin RS, Whitaker S, Pratter MR, Millard CE, Tarpey JT, Corwin RW. The transiency of oropharyngeal colonization of gram-negative bacilli in residents of a skilled nursing facility. Chest. 1982;81:31-35. PUBMED
10. Abrutyn E, Mossey J, Levison M, Boscia J, Pittsakis P, Kaye D. Epidemiology of asymptomatic bacteriuria in elderly ambulatory nonhospitalized women. JAMA. 1987;257:1067-1071. FREE FULL TEXT
11. Nicolle LE. Urinary tract infection in the institutionalized elderly. Infect Dis Clin Pract. 1992;1:68-71.
12. Mims AD, Norman DC, Yamamura RH, Yoshikawa TT. Clinically inapparent (asymptomatic) bacteriuria in ambulatory elderly men: epidemiological, clinical, and microbiological findings. J Am Geriatr Soc. 1990;38:1209-1214. PUBMED
13. Galpin JE, Chow AW, Bayer AS, Guze LB. Sepsis associated with decubitus ulcers. Am J Med. 1976;61:346-350. PUBMED
14. Lara LL, Troop PR, Beadleson-Baird M. The risk of urinary tract infection in bowel-incontinent men. J Gerontol Nurs. 1990;16:24-26. PUBMED
15. Garibaldi RA, Brodine S, Matsumiya S. Infections among patients in nursing homes: policies, prevalence, and problems. N Engl J Med. 1981;305:731-735. PUBMED
16. Magaziner J, Tenney JH, Deforge B, Hebel JR, Muncie HL Jr. Prevalence and characteristics of nursing-home acquired infections in the aged. J Am Geriatr Soc. 1991;39:1071-1078. PUBMED
17. Castle SC, Norman DC, Yeh M, Miller D, Yoshikawa TT. Fever response in elderly nursing home residents: are the older truly colder? J Am Geriatr Soc. 1991;39:853-857. PUBMED
18. Norman D, Grahn D, Yoshidawa T. Fever and aging. J Am Geriatr Soc. 1985;33:859-893. PUBMED
19. Gleckman R, Hibert D. Afebrile bacteremia: a phenomenon in geriatric patients. JAMA. 1981;248:1478-1481.
20. Downton J, Andrews K, Puxty J. 'Silent' pyrexia in the elderly. Age Ageing. 1987;16:41-44. FREE FULL TEXT
21. Finkelstein MS, Petkun WM, Freedman ML, Antopol SC. Pneumococcal bacteremia in adults: age-dependent differences in presentation and in outcome. J Am Geriatr Soc. 1983;31:19-27. PUBMED
22. Deal WB. Unusual manifestation of infectious diseases in the aged. Geriatrics. 1979;31:77-84.
23. Marrie TJ, Durant H, Kwan C. Nursing home-acquired pneumonia: a case-control study. J Am Geriatr Soc. 1986;34:697-702. PUBMED
24. Saltzman RL, Peterson PK. Immunodeficiency of the elderly. Rev Infect Dis. 1987;9:1127-1138. PUBMED
25. Rosenberg JS, Gilman SC, Feldman JD. Effects of aging on cell cooperation and lymphocyte responsiveness to cytokines. J Immunol. 1983;130:1754-1758. ABSTRACT
26. Olive KE, Berk SL. Infections in the nursing home. Clin Geriatr Med. 1992;8:821-834. PUBMED
27. Rollins CJ, Thomson C. Nutrition. In: Bressler R, Katz MD, eds. Geriatric Pharmacology. New York, NY: McGraw-Hill International Book Co; 1993:9-39.
28. Morley JE, Mooradian AD, Silver AJ, Heber D, Alfin-Slater RB. Nutrition in the elderly. Ann Intern Med. 1988;109:890-894. FREE FULL TEXT
29. Silver AJ, Morley JE, Strome LS, Jones D, Vickers L. Nutritional status in an academic nursing home. J Am Geriatr Soc. 1988;36:487-491. PUBMED
30. Rudman D, Mattson DE, Nagraj HS, Caindec N, Rudman IW, Jackson DL. Antecedents of death in the men of a Veterans Administration nursing home. J Am Geriatr Soc. 1987;35:496-502. PUBMED
31. Rudman D, Arora VD, Feller AG, Morley JE. Epidemiology of malnutrition in nursing homes. In: Morley JE, Glick Z, Rubenstein LZ, eds. Geriatric Nutrition: A Comprehensive Review. New York, NY: Raven Press; 1990:325-332.
32. Shaver HJ, Loper JA, Lutes RA. Nutritional status of nursing home patients. JPEN J Parenter Enteral Nutr. 1980;4:367-370. FREE FULL TEXT
33. Scheckler WE, Peterson PJ. Infections and infection control among residents of eight rural Wisconsin nursing homes. Arch Intern Med. 1986;146:1981-1984. FREE FULL TEXT
34. Setia U, Serventi I, Lorenz P. Bacteremia in a long-term care facility: spectrum and mortality. Arch Intern Med. 1984;144:1633-1635. FREE FULL TEXT
35. Rudman D, Hontanosas A, Cohen Z, Mattson DE. Clinical correlates of bacteremia in a Veterans Administration extended care facility. J Am Geriatr Soc. 1988;6:726-732.
36. Muder RR, Brennan C, Wagener MM, Goetz AM. Bacteremia in a long-term care facility: a five-year prospective study of 163 consecutive episodes. Clin Infect Dis. 1992;14:647-654. FREE FULL TEXT
37. McCue JD. Empiric antibiotic therapy for the frail elderly. Infect Dis Clin Pract. In press.
38. Finnegan TP, Austin TW, Cape RDT. A 12-month fever surveillance study in a veteran's long-stay institution. J Am Geriatr Soc. 1985;33:590-594. PUBMED
39. Alvarez S, Shell CG, Woolley TW, Berk SL, Smith JK. Nosocomial infections in long-term facilities. J Gerontol. 1988;43:M9-M17. ABSTRACT
40. Nicolle LE, Mclntyre M, Zacharias H, MacDonell JA. Twelve-month surveillance of infections in institutionalized men. J Am Geriatr Soc. 1984;32:513-519. PUBMED
41. Garb JL, Brown RB, Garb JR. Differences in etiology of pneumonias in nursing home and community patients. JAMA. 1972;240:2169-2172.
42. Peterson PK, Stein D, Guay DRP, et al. Prospective study of lower respiratory tract infections in an extended-care nursing home program: potential role of oral ciprofloxacin. Am J Med. 1988;85:164-171. PUBMED
43. Magnuson MH, Robb SS. Nosocomial infections in a long-term care facility. Am J Infect Control. 1980;8:12-17. PUBMED
44. Yoshikawa TT. Pneumonia, UTI, and decubiti in the nursing home: optimal management. Geriatrics. 1989;44:32-43. PUBMED
45. Yoshikawa TT. Unique aspects of urinary tract infection in the geriatric population. Gerontology. 1984;30:339-341. PUBMED
46. Crossley KB, Thurn JB. Nursing home-acquired pneumonia. Semin Respir Infect. 1989;4:64-72. PUBMED
47. Gaynes RP, Weinstein RA, Chamberlin W, Kabins SA. Antibiotic-resistant flora in nursing home patients admitted to the hospital. Arch Intern Med. 1985;145:1804-1807. FREE FULL TEXT
48. Dontas AS. Urinary-tract infection in nursinghome residents. In: Vergese A, Berk SL, eds. Infections in Nursing Homes and Long-term Care Facilities. Basel, Switzerland: S Karger Publishers; 1990:114.
49. Nicolle LE, Muir P, Harding GKM, Norris M. Localization of urinary tract infection in elderly, institutionalized women with asymptomatic bacteriuria. J Infect Dis. 1988;157:65-70. FREE FULL TEXT
50. Ouslander JG, Greengold B, Chen S. Complications of chronic indwelling urinary catheters among nursing home patients: a prospective study. J Urol. 1987;138:1191-1195. PUBMED
51. McCue JD. Urinary tract infections in the elderly. Pharmacotherapy. 1993;13:51S-53S. PUBMED
52. Rowe JW. Aging, renal function and response to drugs. Aging (Milano). 1981;16:115-130.
53. Marchbanks CR, Mikolich DJ, Mayer KH, Zinner SH, Dudley MN. Pharmacokinetics and bioavailability of intravenous-to-oral enoxacin in elderly patients with complicated urinary tract infections. Antimicrob Agents Chemother. 1990;34:1966-1972. FREE FULL TEXT
54. Cox CE, Drylie DM, Klimberg I, et al. A multicenter, double-blind, trimethoprim-sulfamethoxazole controlled study of enoxacin in the treatment of patients with complicated urinary tract infections. J Urol. 1989;141:575-578. PUBMED
55. Bjork DT, Pelletier LL, Tight RR. Urinary tract infections with antibiotic resistant organisms in catheterized nursing home patients. Infect Control. 1984;5:173-180. PUBMED
56. Stamm WE, Hooton TM. Management of urinary tract infections in adults. N Engl J Med. 1993;329:1328-1334. PUBMED
57. Allman RM. Pressure ulcers among the elderly. N Engl J Med. 1989;320:850-853. PUBMED
58. Sugarman B. Pressure sores and underlying bone infection. Arch Intern Med. 1987;147:553-555. FREE FULL TEXT
59. Bryan LS, Dew CE, Reynolds DVM. Bacteremia associated with decubitus ulcers. Arch Intern Med. 1983;143:2093-2095. FREE FULL TEXT
60. Glenchur H, Patel BS, Pathmarajah C. Transient bacteremia associated with débridement of decubitus ulcers. Mil Med. 1981;146:432-433. PUBMED
61. Richer M, LeBel M. Pharmacokinetics of fluoroquinolones in selected populations. In: Hooper DC, Wolfson JS, eds. Quinolone Antimicrobial Agents. 2nd ed. Washington, DC: American Society for Microbiology; 1993:225-244.
62. Ball P. Adverse reactions and interactions of fluoroquinolones. Clin Invest Med. 1989;12:28-34. PUBMED
63. Andriole VT. The Quinolones. New York, NY: Academic Press Inc; 1988.
64. Hooper DC, Wolfson JS. Fluoroquinolone antimicrobial agents. N Engl J Med. 1991;324:384-394. PUBMED
65. Hooper DC, Wolfson JS, eds. Quinolone Antimicrobial Agents. 2nd ed. Washington, DC: American Society for Microbiology; 1993.
66. Sanders WE, Sanders CC, eds. Fluoroquinolones in the Treatment of Infectious Diseases. Glenview, III: Physicians & Scientists Publishing; 1990.
67. Ciprofloxacin: major advances in intravenous and oral quinolone therapy. Am J Med. 1989;87(suppl_5A):1S-287S. PUBMED
68. Second international symposium on new quinolones. Rev Infect Dis. 1989;11(S5):S1-S1430.
69. International symposium on new quinolones. Rev Infect Dis. 1988:10(S1):S1-S271. PUBMED
70. Neu HC, Percival A, Lode H. Ciprofloxacin: a major advance in quinolone chemotherapy. Am J Med. 1987;82(suppl 4A):1-404. PUBMED
71. Fostini R, Girelli M, Dalle Vedove P, Benedetti M, Recchia G. Safety profile of ofloxacin in elderly patients. Drugs Exp Clin Res. 1988;14:393-395. PUBMED
72. Bruck K, Blomer R. Efficacy and safety of ofloxacin in elderly patients. Int J Pharmacol Res. 1987;7:195-198.
73. Paton JH, Reeves DS. Fluoroquinolone antibiotics: microbiology, pharmacokinetics and clinical use. Drugs. 1988;36:193-228. PUBMED
74. Ofloxacin: a pharmacodynamic advance in quinolone antimicrobial therapy. Am J Med. 1989;87(suppl 6C):1S-81S. PUBMED
75. Lomefloxacin: development of a once-a-day quinolone. Am J Med. 1992;92(suppl 4A):1S-137S. PUBMED
76. Stuck AE, Kim DK, Frey FJ. Fleroxacin clinical pharmacokinetics. Clin Pharmacokinet. 1992;22:116-131. PUBMED
77. Gerding DN, Hitt JA. Tissue penetration of the new quinolones in humans. Rev Infect Dis. 1989;11(suppl 5):S1046-S1057. PUBMED
78. McCue JD. Antibiotic dosing for the renally impaired elder. P & T. In press.
79. Davey PG. Post-marketing surveillance of the quinolones: a view from Great Britain. Rev Infect Dis. 1989;11(suppl 5):S102-S107.
80. Outman WR. Enoxacin: a new fluoroquinolone antibiotic. Hosp Formulary. 1990;25:32-40.
81. Geddes AM. Safety of fleroxacin in clinical trials. Am J Med. 1993;94(suppl 3A):201S-203S. PUBMED
82. Hooper DC, Wolfson JS. Adverse effects. In: Hooper DC, Wolfson JS, eds. Quinolone Antimicrobial Agents. 2nd ed. Washington, DC: American Society for Microbiology; 1993:489-512.
83. McCue JD, Zandt J. Acute psychotic reactions associated with the use of ciprofloxacin or trimethoprin-sulfamethoxazole. Am J Med. 1991;90:528-529. PUBMED
84. McCue JD. The advantages of simplicity in long-term care drug regimens. In: McCue JD, Tessier EG, Gaziano P, eds. Geriatric Handbook of Drug Use in Long-term Care. Baltimore, Md: Williams & Wilkins; 1993.
85. Nix DE. Drug-drug interactions with fluoroquinolone antimicrobial agents. In: Hooper DC, Wolfson JS, eds. Quinolone Antimicrobial Agents. 2nd ed. Washington, DC: American Society for Microbiology; 1993:245-258.
86. Budnick LD, Schaefler S. Ciprofloxacinresistant methicillin-resistant Staphylococcus aureus in New York health care facilities, 1988: The New York MRSA Study Group. Am J Public Health. 1990;80:810-813. PUBMED
87. Bradley SF, Terpenning MS, Ramsey MA, et al. Methicillin-resistant Staphylococcus aureus: colonization and infection in a long-term care facility. Ann Intern Med. 1991;115:417-422. FREE FULL TEXT
88. Muder RR, Brennen C, Wagener MM, Vickers RM, Rihs JD, Hancock GA. Methicillinresistant staphylococcal colonization and infection in a long-term care facility. Ann Intern Med. 1991;114:107-112. FREE FULL TEXT
89. Thys JP, Jacobs F, Byl B. Role of quinolones in the treatment of bronchopulmonary infections, particularly pneumococcal and community-acquired pneumonia. Eur J Clin Microbiol Infect Dis. 1991;10:304-315. PUBMED
90. Sanders WE, Morris JF, Alessi P, Makris AT, McCloskey RV, Trenholme GM. Oral ofloxacin for the treatment of acute bacterial pneumonia: use of a nontraditional protocol to compare experimental therapy with 'usual care' in a multicenter clinical trial. Am J Med. 1991;91:261-266. PUBMED
91. Lode H, Wiley E, Olshewski P, Sievers H, Wintemantel M, Baetz R. Prospective randomized trials of new quinolones versus beta-lactam antibiotics in lower respiratory infections. Scand J Infect Dis Suppl. 1990;68:50-55. PUBMED
92. Gentry LO. Therapy with newer oral betalactam and quinolone agents for infections of the skin and skin structures: a review. Clin Infect Dis. 1992;14:285-297. FREE FULL TEXT
93. Mehr MR, Foxman B, Colombo P. Risk factors for mortality from lower respiratory infections in nursing home patients. J Fam Pract. 1992;34:585-591. PUBMED
94. Trenholme GM, Schmitt GM, Spear J, Gvazdinskas LC, Levin S. Randomized study of intravenous/oral ciprofloxacin versus ceftazidime in hospital and nursing home patients with lower respiratory infections. Am J Med. 1989;87(suppl 5A):116S-118S. PUBMED
95. Hirata-Dulas CA, Stein DJ, Guay DR, Gruninger RP, Peterson PK. A randomized study of ciprofloxacin versus ceftriaxone in the treatment of nursing home-acquired lower respiratory infections. J Am Geriatr Soc. 1991;39:979-985. PUBMED
96. Nicolle LE, Degelau J, Alessi P, Cullison J, Meyers B. Ofloxacin use in a geriatric population. Chemotherapy. 1991;37(suppl 1):49-54. PUBMED
97. Preheim LC, Cuevas TA, Rocaforte JS, Mellencam MA, Bittner MJ. Oral ciprofloxacin in the treatment of elderly patients with complicated UTI due to trimethoprim-sulfamethoxazole resistant bacteria. Am J Med. 1987;82:295-300. PUBMED
98. Cox CE. Ofloxacin in the management of complicated urinary tract infection, including prostatitis. Am J Med. 1989;87(suppl 6C):61S-68S. PUBMED
99. Cox CE, Tack KJ. Safety and efficacy of ofloxacin vs trimethoprim-sulfamethoxazole for complicated urinary tract infections. Rev Infect Dis. 1988;10(suppl 1):S175-S176.
100. Malverni R, Glauser MP. Comparative studies of fluoroquinolones in the treatment of urinary tract infections. Rev Infect Dis. 1988;10(suppl 1):S153-S163. PUBMED
101. Naber KG. Use of quinolones in urinary tract infections and prostatitis. Rev Infect Dis. 1989;11(suppl 5):S1321-S1337. PUBMED
102. Phillips SL, Branaman-Phillips J. The use of intramuscular cefoperazone versus intramuscular ceftriaxone in patients with nursing home-acquired pneumonia. J Am Geriatr Soc. 1993;41:1071-1074. PUBMED
103. Peterson PK, Stein D, Guay DR, et al. Prospective study of lower respiratory infections in an extended-care nursing home program: potential role of oral ciprofloxacin. Am J Med. 1988;85:164-171. PUBMED
104. Fass RJ, Plouffe JF, Russell JA. Intravenous/oral ciprofloxacin versus ceftazidime in the treatment of serious infections. Am J Med. 1989;87(suppl 5A):136S-137S. PUBMED
105. Snydman DR, Barza M, McGowan K, et al. Randomized comparative trial of ciprofloxacin for treatment of patients with osteomyelitis. Rev Infect Dis. 1989;11(suppl 5):S1271-S1272.
106. Thys JP, Jacobs F, Motte S. Quinolones in the treatment of lower respiratory tract infections. Rev Infect Dis. 1989;11(suppl 5):S1212-S1219. PUBMED
107. Scully BE. Therapy of respiratory tract infections with quinolone antimicrobial agents. In: Hooper DC, Wolfson JS, eds. Quinolone Antimicrobial Agents. 2nd ed. Washington, DC: American Society for Microbiology; 1993:339-362.
108. Perez-Ruvalcaba JA, Quintero-Perez NP, Morales-Reyes JJ, Huitron-Ramirez JA, Rodriguez-Chagollan JJ, Rodriguez-Noriega E. Double blind comparison of ciprofloxacin with cefotaxime in the treatment of skin and skin structure infections. Am J Med. 1987;82:242-246. PUBMED
109. Ramirez-Ronda CH, Saavedra S, Rivera-Vazquez CR. Comparative, double-blind study of oral ciprofloxacin and intravenous cefotaxime in skin and skin-structure infections. Am J Med. 1987;82:220-223. PUBMED
110. Gentry LO, Ramirez-Ronda CH, Rodriguez-Noriega E, Thadepalli H, del Rosal PL, Ramirez P. Oral ciprofloxacin vs parenteral cefotaxime in the treatment of difficult skin and skin-structure infections: a multicenter trial. Arch Intern Med. 1989;149;2570-2583.
111. Dominguez J, Palma F, Vega ME, Magana JL, Ortiz G, Teresa-Hojyo M. Prospective, controlled, randomized non-blind comparison of intravenous/oral ciprofloxacin with intravenous ceftazidime in the treatment of skin or softtissue infections. Am J Med. 1989;87(suppl 5A):136S-137S. PUBMED
112. Gentry LO, Koshdel A. Intravenous/oral ciprofloxacin versus intravenous ceftazidime in the treatment of serious gram-negative infections of the skin and skin structure. Am J Med. 1989;87(suppl 5A):132S-135S. PUBMED
113. Gentry LO, Rodriguez-Gomez G, Zeluff BJ, Khoshdel A, Price M. A comparative evaluation of oral ofloxacin versus intravenous cefotaxime therapy for serious skin and skin structure infections. Am J Med. 1989;87(suppl 6C):57S-60S. PUBMED
114. McCue JD. Antibiotic selection in long-term care. In: McCue JD, Tessier ET, Gaziano P, eds. Hand-book of Drug Use for Long-term Care and the Frail Elderly. Baltimore, Md: Williams & Wilkins; 1993:28-42.
115. Trimethoprim-sulfamethoxazole revisited. Rev Infect Dis. 1982;4:196-618. PUBMED
116. Progress and perspectives on beta-lactamase inhibition: a review of Augmentin. Postgrad Med. 1984;suppl:3-295.
117. Ceftin. Hosp Formulary. 1988;23(suppl C):1-40.
118. Borin MT. A review of the pharmacokinetics of cefpodoxime proxetil. Drugs. 1992;42:(suppl 3):13-21.
119. Nelson JD. Cefuroxime: a cephalosporin with unique applicability to pediatric practice. Pediatr Infect Dis. 1983;2:394-396. PUBMED
120. Cefixime: clinical overview of a new oral thirdgeneration cephalosporin. Am J Med. 1988;85(suppl 3A):1-25. PUBMED
121. Evaluation of new oral antimicrobial agents and the experience with cefprozil: a broadspectrum oral cephalosporin. Clin Infect Dis. 1992;14(suppl 2):S1-S272. PUBMED
122. Mott PD, Barker WH. Treatment decisions for infections occurring in nursing home residents. J Am Geriatr Soc. 1988;36:820-824. PUBMED
123. Fabiszewski KJ, Volicer B, Volicer L. Effect of antibiotic treatment on outcome of fevers in institutionalized Alzheimer patients. JAMA. 1990;263:3168-3172. FREE FULL TEXT