Terazosin in the Treatment of Benign Prostatic Hyperplasia
Michael K. Brawer, MD;
George Adams, MD;
Howard Epstein, MD;
the Terazosin Benign Prostatic Hyperplasia Study Group
Arch Fam Med. 1993;2(9):929-935.
To evaluate the efficacy and tolerability of terazosin, a long-acting selective 1-receptor antagonist, in patients with benign prostatic hyperplasia.
Design and Setting
Randomized, double-blind, multicenter (eight government and private facilities), placebo-controlled study.
Men aged 45 years or older, with qualifying signs and symptoms of benign prostatic hyperplasia (n=160).
Terazosin or placebo once daily, with terazosin dosage titrated to the patient's response. After a 4-week placebo lead-in, 1 to 10 mg of terazosin or placebo was administered for 24 weeks.
Decreases in mean Boyarsky scores for obstructive and irritative symptoms and total scores and increases in peak urine flow rate.
Terazosin-treated patients had decreases in Boyarsky obstructive, irritative, and total scores of 3.3 (52%), 1.3 (29%), and 4.6 (42%), respectively, compared with decreases of 0.7 (12%), 0.4 (9%), and 1.1 (11%), respectively, in the placebo group (P<.05). Peak urine flow increased by a mean of 2.6 mL/s (30%) in terazosin-treated patients and 1.2 mL/s (14%) in placebo-treated patients (P.05). Adverse events that differed significantly in the two groups were dizziness (19% in the terazosin group vs 5% in the placebo group) and urinary tract infection (1% in the terazosin group vs 10% in the placebo group).
These results suggest that terazosin given once daily in doses up to 10 mg alleviates symptoms and improves peak urine flow rate in men with benign pro-static hyperplasia and has an acceptable adverse event profile.
From Veterans Affairs Medical Center, Seattle, Wash (Dr Brawer); Norwood Clinic, Birmingham, Ala (Dr Adams); and Department of Surgery, University of Florida, Gainesville (Dr Epstein). The members of the Terazosin Benign Prostatic Hyperplasia Study Group are listed at the end of this article.
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