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  Vol. 2 No. 9, September 1993 TABLE OF CONTENTS
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Terazosin in the Treatment of Benign Prostatic Hyperplasia

Michael K. Brawer, MD; George Adams, MD; Howard Epstein, MD; the Terazosin Benign Prostatic Hyperplasia Study Group

Arch Fam Med. 1993;2(9):929-935.


Abstract

Objective
To evaluate the efficacy and tolerability of terazosin, a long-acting selective {alpha}1-receptor antagonist, in patients with benign prostatic hyperplasia.

Design and Setting
Randomized, double-blind, multicenter (eight government and private facilities), placebo-controlled study.

Patients
Men aged 45 years or older, with qualifying signs and symptoms of benign prostatic hyperplasia (n=160).

Interventions
Terazosin or placebo once daily, with terazosin dosage titrated to the patient's response. After a 4-week placebo lead-in, 1 to 10 mg of terazosin or placebo was administered for 24 weeks.

Outcome Measures
Decreases in mean Boyarsky scores for obstructive and irritative symptoms and total scores and increases in peak urine flow rate.

Results
Terazosin-treated patients had decreases in Boyarsky obstructive, irritative, and total scores of 3.3 (52%), 1.3 (29%), and 4.6 (42%), respectively, compared with decreases of 0.7 (12%), 0.4 (9%), and 1.1 (11%), respectively, in the placebo group (P<.05). Peak urine flow increased by a mean of 2.6 mL/s (30%) in terazosin-treated patients and 1.2 mL/s (14%) in placebo-treated patients (P≤.05). Adverse events that differed significantly in the two groups were dizziness (19% in the terazosin group vs 5% in the placebo group) and urinary tract infection (1% in the terazosin group vs 10% in the placebo group).

Conclusions
These results suggest that terazosin given once daily in doses up to 10 mg alleviates symptoms and improves peak urine flow rate in men with benign pro-static hyperplasia and has an acceptable adverse event profile.



Author Affiliations

From Veterans Affairs Medical Center, Seattle, Wash (Dr Brawer); Norwood Clinic, Birmingham, Ala (Dr Adams); and Department of Surgery, University of Florida, Gainesville (Dr Epstein). The members of the Terazosin Benign Prostatic Hyperplasia Study Group are listed at the end of this article.



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Men's Health Issues
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